As far as comfort food goes, few dishes deliver the perfect marriage of velvety cheese and deep, smoky flavor quite like this Brisket Mac and Cheese. I’ll never forget the first time I introduced this mashup at a weekend cook-out: tender strands of leftover brisket crisped to golden edges, entwined with elbow macaroni bathed in a three-cheese sauce so silky that it practically begged you to take just one more bite. It really lives up to its subtitle—Cheesy comfort meets smoky brisket in this ultimate mac ’n’ cheese mashup! Each forkful is like a warm hug from the inside out, and once you’ve mastered this Intermediate-level recipe, it’s destined to become your go-to for lunch or dinner gatherings.
This dish isn’t just about indulgence; it’s a celebration of technique too. With 20 minutes of prep, 45 minutes of baking, and a quick 5-minute rest before diving in, you’ll end up with a bubbly casserole that’s as satisfying to make as it is to eat. Plus, at around 700 calories per serving, you know you’re treating yourself right. The combination of whole milk, heavy cream, and a trio of sharp cheddar, stretchy mozzarella, and nutty Parmesan creates a richness that coats every noodle. A whisper of smoked paprika, garlic, and onion powder deepens the flavor profile, while a crisp panko topping adds that crave-worthy crunch. Whether you’re repurposing leftover barbecue brisket or cooking a fresh cut just for this recipe, get ready for a crowd-pleasing, fork-licking feast that will have everyone begging for seconds.
KEY INGREDIENTS IN BRISKET MAC AND CHEESE
Before we dive into the kitchen, let’s talk about the star players that make this mac and cheese sing. Every ingredient has its moment—from the smoky brisket that anchors the dish to the trio of cheeses that give it that signature creaminess. Here’s what you need and why each component matters:
- Brisket: Provides tender, smoky meat that adds depth and a hearty texture once shredded and seared.
- Elbow Macaroni: The classic pasta shape that traps sauce in every little curve, ensuring each bite is coated in cheesy goodness.
- Whole Milk: The backbone of the sauce, lending a smooth richness that melds beautifully with cream.
- Heavy Cream: Boosts the creaminess factor, creating a lusciously thick sauce that clings to the pasta.
- Sharp Cheddar Cheese: Offers a tangy, savory punch that defines the classic mac and cheese flavor.
- Mozzarella Cheese: Contributes gooey stretch and a mild, milky counterpoint to sharper cheeses.
- Parmesan Cheese: Adds a salty, nutty complexity that rounds out the cheese sauce.
- Unsalted Butter: Combines with flour to form a roux, creating the perfect base for a smooth sauce.
- All-Purpose Flour: Thickens the milk and cream into a velvety cheese sauce when cooked into the roux.
- Garlic Powder: Infuses the sauce with savory warmth without overpowering the cheese.
- Onion Powder: Brings a subtle sweetness and depth, enhancing the overall flavor profile.
- Smoked Paprika: Introduces an extra layer of smokiness to complement the brisket.
- Salt and Pepper: Essential for seasoning and balancing the flavors throughout the dish.
- Olive Oil: Used to crisp up the shredded brisket, adding texture and a hint of fruitiness.
- Panko Breadcrumbs: Sprinkled on top for a golden, crunchy finish.
- Fresh Parsley: A bright, herbaceous garnish that lifts the dish with color and freshness.
HOW TO MAKE BRISKET MAC AND CHEESE
Let’s walk through the process of transforming these ingredients into a bubbling, decadent bake. With clear steps and key techniques highlighted, you’ll be able to recreate this crowd-pleaser in your own kitchen with confidence and flair.
1. Cook the elbow macaroni according to the package instructions until it’s al dente. Drain well and set aside in the colander so it doesn’t overcook while you prepare the sauce.
2. In a large skillet, heat the olive oil over medium heat. Add the shredded brisket and sear for about 5 minutes, tossing occasionally, until the edges become slightly crispy. Remove from the skillet and set aside on a plate.
3. In a separate saucepan, melt the unsalted butter over medium heat. Once it’s fully melted, whisk in the all-purpose flour to form a roux. Cook this mixture for 1–2 minutes, stirring constantly, until it turns a light golden hue.
4. Slowly pour in the whole milk and heavy cream, whisking continuously to keep the sauce completely smooth. Continue cooking and whisking frequently for about 5–7 minutes, until the mixture thickens and coats the back of a spoon.
5. Season the sauce by stirring in the garlic powder, onion powder, smoked paprika, and salt and pepper to taste. Once the sauce is luscious and has reached the right consistency, reduce the heat to low.
6. Gradually add the shredded sharp cheddar, mozzarella, and Parmesan cheeses, stirring each addition until fully melted and the sauce is silky.
7. Fold in the cooked macaroni, tossing gently so every noodle is enveloped in cheese.
8. Carefully incorporate the seared brisket strands, distributing the meat evenly throughout the mac and cheese.
9. Transfer the mixture into a greased 9×13-inch baking dish. Evenly sprinkle the panko breadcrumbs over the top for that perfect crunch.
10. Bake in a preheated oven at 350°F (175°C) for 15–20 minutes, or until the top is golden and the edges are bubbly.
11. Remove from the oven and let the casserole rest for about 5 minutes. Garnish with freshly chopped parsley before serving to add a pop of color and freshness.
SERVING SUGGESTIONS FOR BRISKET MAC AND CHEESE
Once your Brisket Mac and Cheese is hot and bubbly from the oven, it’s time to think about presentation and pairing to make the meal truly unforgettable. Whether you’re hosting a laid-back family dinner, a backyard barbecue, or a game-day spread, the way you serve this dish can elevate it from delicious to downright spectacular. From complementary sides that cut through the richness to creative plating ideas that impress guests, there are plenty of ways to tailor this hearty casserole to your occasion. Let’s explore four simple yet effective ways to serve up your Brisket Mac and Cheese like a seasoned home cook:
- Add a Zesty Kick: Top each serving with sliced fresh jalapeños or a drizzle of your favorite hot sauce. The heat provides a lively contrast to the creamy cheese sauce and smoky brisket, waking up the palate with every bite.
- Pair with a Crisp Side: Balance out the richness by serving alongside a bowl of tangy coleslaw or a light mixed green salad tossed in a citrus vinaigrette. The acidity and crunch are a perfect counterpoint.
- Serve in Individual Ramekins: Portion the mac and cheese into small oven-safe dishes for a trendy, restaurant-style presentation. This makes it easy for guests to grab their own and keeps the topping extra crunchy.
- Drizzle with BBQ Sauce: For the true barbecue enthusiast, finish each plate with a swirl of smoky-sweet BBQ sauce. It amplifies the brisket flavor and adds another layer of saucy goodness.
HOW TO STORE BRISKET MAC AND CHEESE
Brisket Mac and Cheese is just as satisfying as leftovers as it is fresh from the oven, and with proper storage, you can preserve those flavors and textures for several days. The key is to cool the casserole safely, pack it in the right containers, and reheat it gently to maintain creaminess and prevent dryness. Here are some tried-and-true methods to keep your dish tasting its best, whether you plan to enjoy it over the next few lunches or want to stash a portion in the freezer for busy weeknights:
- Refrigeration: Allow the casserole to cool to room temperature, then transfer it into an airtight container. Store in the refrigerator for up to 4 days, making sure to seal out excess air to prevent the top from drying out.
- Freezing: For longer storage, divide the mac and cheese into freezer-safe containers or heavy-duty zip-top bags. Remove as much air as possible, label with the date, and freeze for up to 3 months. Thaw overnight in the fridge before reheating.
- Portion Control: Freeze individual servings using muffin tins or small containers, then pop out portions as needed. This method makes it easy to reheat single servings without warming the entire batch.
- Gentle Reheating: To revive that creamy texture, reheat portions in the oven at 325°F (165°C) for about 10–15 minutes, covered with foil. Alternatively, microwave on medium power in 30-second intervals, stirring in between, and add a splash of milk or cream if it looks dry.
CONCLUSION
This Brisket Mac and Cheese has everything you could want in a comfort-food recipe: tender, smoky brisket crisped to perfection, three cheeses melding into a lusciously smooth sauce, elbow macaroni ready to soak up all that flavor, and a golden panko topping that adds a delightful crunch. From the first whisk of the roux to the final broil under the oven’s heat, every step builds layers of taste and texture that make this dish an Instant crowd-pleaser. With roughly 20 minutes of hands-on prep and about 45 minutes of baking, you can turn leftover barbecue or a fresh cut of brisket into a decadent family favorite that’s perfect for lunch or dinner gatherings.
Feel free to print this article and save it for your next menu rotation, or bookmark it so you can revisit the step-by-step instructions whenever the craving strikes. You’ll find a handy FAQ section below to troubleshoot any questions you might have about substitutions, technique, or ingredient swaps. If you give this recipe a try, I’d love to hear how it goes—drop a comment with your thoughts, questions, or any tips you discovered along the way. Happy cooking, and here’s to beautifully cheesy, irresistibly smoky Brisket Mac and Cheese every time!

Brisket Mac and Cheese
Description
Tender brisket pieces crisped in olive oil, enveloped in a silky three-cheese sauce, tossed with elbow macaroni and baked under golden panko for a smoky, indulgent comfort meal.
Ingredients
Instructions
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Begin by cooking the elbow macaroni according to the package instructions. Drain and set aside.
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In a large skillet, heat the olive oil over medium heat. Add the shredded brisket and cook until slightly crispy, about 5 minutes. Remove from the skillet and set aside.
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In a large saucepan, melt the butter over medium heat. Once melted, whisk in the flour to form a roux, cooking for 1-2 minutes until golden.
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Slowly whisk in the whole milk and heavy cream, ensuring the mixture is smooth. Continue cooking, whisking frequently, until the sauce thickens, about 5-7 minutes.
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Stir in the garlic powder, onion powder, smoked paprika, and salt and pepper to taste. Once the sauce has thickened, reduce the heat to low.
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Gradually add the shredded cheddar, mozzarella, and Parmesan cheeses to the sauce, stirring until melted and smooth.
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Add the cooked macaroni to the cheese sauce, stirring to coat evenly.
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Gently fold in the seared brisket to the mac and cheese, mixing well.
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Pour the mac and cheese into a greased 9x13-inch baking dish. Top with the panko breadcrumbs for a crunchy topping.
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Bake in a preheated oven at 350°F (175°C) for 15-20 minutes, or until the top is golden and bubbly.
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Garnish with freshly chopped parsley before serving.
Note
- For extra flavor, you can add a dash of hot sauce or a few dashes of Worcestershire sauce to the cheese sauce.
- If you prefer a creamier texture, increase the amount of cream and decrease the milk.
- Leftover brisket is perfect for this recipe, making it a great way to repurpose any extra brisket.
- This dish can be made ahead and baked just before serving for an easy, crowd-pleasing meal.